[["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0019457","therapy related acute myeloid leukemia and myelodysplastic syndrome",[],["PMC:7413899"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005105","melanoma",[],["PMC:8469858","PMC:8997563","PMC:8357258","PMC:8992561","PMC:8652404"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0004947","B-cell acute lymphoblastic leukemia",[],["PMC:7611942"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","HP:0001744","Splenomegaly",[],["PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0100430","fibrotic liver disease",[],["PMC:6536582","PMC:7013198"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0100096","COVID-19",[],["PMC:9167582","PMC:8282443"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0020320","acute myeloblastic leukemia with maturation",[],["PMC:7015993","PMC:8469858","PMC:9135597","PMC:6679203","PMC:8179919"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0018881","myelodysplastic syndrome",[],["PMC:8324480","PMC:8357258","PMC:6679203","PMC:9261311"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0018874","acute myeloid leukemia",[],["PMC:7015993","PMC:8469858","PMC:9135597","PMC:6851194","PMC:6679203"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0018177","glioblastoma",[],["PMC:9354051","PMC:7912673","PMC:9135597","PMC:8469858","PMC:8616823"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0009831","malignant pancreatic neoplasm",[],["PMC:7913382","PMC:7408754","PMC:8349827","PMC:8179919","PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005494","triple-negative breast carcinoma",[],["PMC:9092944","PMC:7696061","PMC:8469858","PMC:8547516","PMC:8833442"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005233","non-small cell lung carcinoma",[],["PMC:7254113","PMC:8541586","PMC:9040166","PMC:7015993","PMC:9058057"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005192","exocrine pancreatic carcinoma",[],["PMC:7913382","PMC:7408754","PMC:8349827","PMC:8179919","PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005191","metastatic melanoma",[],["PMC:9092944","PMC:8750474","PMC:8773625","PMC:7072236"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005184","pancreatic ductal adenocarcinoma",[],["PMC:7583676","PMC:8349827","PMC:8508406"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005086","renal cell carcinoma",[],["PMC:8652404"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005061","lung adenocarcinoma",[],["PMC:7408754","PMC:7015993","PMC:8581356","PMC:8179919","PMC:8833442"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0006047","pancreatic adenocarcinoma",[],["PMC:8469858","PMC:7466866","PMC:7595263"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005065","mesothelioma",[],["PMC:9092944","PMC:8469858","PMC:8992561"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005059","leukemia",[],["PMC:7611942"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0000494","renal fibrosis",[],["PMC:8335678"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","HP:0004808","acute myeloid leukemia",[],["PMC:6679203","PMC:9157040"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0013209","metabolic dysfunction-associated steatotic liver disease",[],["PMC:8698495"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0008903","lung cancer",[],["PMC:9305809","PMC:9092944"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0007254","breast cancer",[],["PMC:9157040","PMC:8282443"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005091","severe acute respiratory syndrome",[],["PMC:9013431","PMC:9284228"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0004992","cancer",[],["PMC:6536582","PMC:7291090","PMC:8948193","PMC:7998716","PMC:7601762"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0008170","ovarian cancer",[],["PMC:8703923","PMC:6896070"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005575","colorectal cancer",[],["PMC:7878213"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0002691","liver cancer",[],["PMC:7013198"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0040679","urothelial carcinoma",[],["PMC:8992561"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0012817","Ewing sarcoma",[],["PMC:7381324"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0011719","gastrointestinal stromal tumor",[],["PMC:8492542"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0011282","tumor suppressor gene on chromosome 11",[],["PMC:8547516"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005138","lung carcinoma",[],["PMC:7397559"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0004970","adenocarcinoma",[],["PMC:7696061"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0008383","rheumatoid arthritis",[],["PMC:7516369"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0002334","hematopoietic and lymphoid system neoplasm",[],["PMC:6718264","PMC:8781146"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0002280","anemia",[],["PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0006292","malignant mesothelioma",[],["PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005240","kidney disorder",[],["PMC:8335678"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0003634","proteinuria",[],["PMC:6536582"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0011996","chronic myelogenous leukemia, BCR-ABL1 positive",[],["PMC:8357258"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005057","large cell neuroendocrine carcinoma",[],["PMC:7925356"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0002714","central nervous system cancer",[],["PMC:8122870"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0007576","esophageal cancer",[],["PMC:8652404"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005627","head and neck cancer",[],["PMC:8652404"]],["DRUGBANK:DB12411","bemcentinib","biolink:treats_or_applied_or_studied_to_treat","MONDO:0005108","viral infectious disease",[],["PMC:7393340"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C4021734","Abnormality of mitochondrial metabolism",{"PMID:34219376":{"object score":"1000","publication date":"2021 Jul 05","sentence":"Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model.","subject score":"790"}},["PMID:34219376"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C3463824","Myelodysplastic Syndromes",{"PMID:32136869":{"object score":"1000","publication date":"2018 Oct","sentence":"The identification of the AXL/Gas6 signalling axis as a key player of myelodysplastic syndrome (MDS) and the potential of the oral selective AXL inhibitor bemcentinib in the treatment of MDS.","subject score":"739"}},["PMID:32136869"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C0041956","Ureteral obstruction",{"PMID:34219376":{"object score":"901","publication date":"2021 Jul 05","sentence":"Serum metabolomics analysis also showed a normalizing amino acid profile in UUO, compared with SHAM-operated mice following bemcentinib treatment.","subject score":"888"}},["PMID:34219376"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C0029162","Dental Health",{"PMID:32440898":{"object score":"901","publication date":"2020 May 21","sentence":"Based on the current observations, it can be assumed that oro-dental health might be significant also prior and during treatment with Bemcentinib for the prevention of MRONJ.","subject score":"1000"}},["PMID:32440898"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C0023467","Acute Myeloid Leukemia",{"PMID:32440898":{"object score":"1000","publication date":"2020 May 21","sentence":"Bemcentinib is a newly developed AXL inhibitor that is currently under investigation in phase II trails for the treatment of acute myeloblastic leukemia (AML).","subject score":"1000"}},["PMID:32440898"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C0016059","Fibrosis",{"PMID:34861551":{"object score":"1000","publication date":"2021 Nov 30","sentence":"Currently, the therapeutical approaches involving selected medications (bemcentinib, pirfenidone and nintedanib) obtained synthetically, and used in clinical practices for fibrosis and cancer management and treatment has shown to be unsatisfactorily, especially during progressive stages of the disease.","subject score":"1000"}},["PMID:34861551"]],["UMLS:C4763383","bemcentinib","treats","UMLS:C0006826","Cancers",{"PMID:34861551":{"object score":"888","publication date":"2021 Nov 30","sentence":"Currently, the therapeutical approaches involving selected medications (bemcentinib, pirfenidone and nintedanib) obtained synthetically, and used in clinical practices for fibrosis and cancer management and treatment has shown to be unsatisfactorily, especially during progressive stages of the disease.","subject score":"1000"}},["PMID:34861551"]],["UMLS:C4763383","bemcentinib","administered_to","UMLS:C0027361","person",{"PMID:35492873":{"object score":"877","publication date":"2022 Mar 15","sentence":"NSCLC-affected individuals with identified    STK11/LKB1     mutations receiving bemcentinib and pembrolizumab demonstrated objective clinical response to combination therapy.","subject score":"1000"}},["PMID:35492873"]],["UMLS:C4763383","bemcentinib","prevents","UMLS:C0042769","Virus Diseases",{"PMID:32736596":{"object score":"1000","publication date":"2020 Jul 31","sentence":"Bemcentinib could potentially reduce viral infection and blocks SARS-CoV-2 spike protein; MEDI3506 is a clinic-ready anti-IL-33 monoclonal antibody with the potential to treat respiratory failure caused by COVID; acalabrutinib is a BTK inhibitor which is anti-viral and anti-inflammatory; zilucoplan is a complement C5 inhibitor which may block the severe inflammatory response in COVID-19 and; nebulised heparin has been shown to bind with the spike protein.","subject score":"1000"}},["PMID:32736596"]]]